Among the ones that have departed here in the last few years: Hardee's, Arby's, KFC, Friendly's, and only one I miss, Backyard Burgers.
Plenty of Hardee's Arby's and KFC around here. Backyard had a significant presence for a short while, but the local franchisee seemed to get caught up in the economic turbulence several years back. They're down to 65 locations, from a high of 171 in 2008.