I have owned several different McIntosh tube amplifiers through the years, and presently own the MC300, the MC275 MkV, and a 4300V.
Although the MC275 Mk IV and MC275 MkV are both very fine amplifiers, in my opinion the MC275 MkV is a superior product. Unless you have a specific reason to need amp gain controls, there is no need to have the additional hardware in the audio circuits. It is just one more place for future audio signal degradation, and/or maintenance. The gain controls were not designed to be used as preamp volume control replacements, so I suspect they will not stand the test of time being used in that manner. If you choose to run a CD directly into the MC275, find a CD player that provides volume control of the analog output, preferably with remote control. Another point, the gain controls only effect the unbalanced inputs on the MC275 Mk VI, so if you use balanced input cables the gain controls are useless.
The other issue that makes the Mk V better is the gold plated speaker binding posts. Having used the terminal strips on several other McIntosh amps, the binding posts on the Mk V amp are far superior. They allow large guage wire to be inserted directly without the need for terminal adapters, and can be tightened by hand, no tools required. The new binding posts also accommodate banana plugs, should you choose this method of quick release termination.
As far as output tubes are concerned, it is a matter of personal preference. The McIntosh KT88 branded tubes are fine tubes, but my preference is for the Genalex Gold Lion KT88 reissue power tubes, and Philips JAN tubes in the 12AX7 and 12AT7 sockets. In my humble opinion, the MC275 MkV with this tube compliment, sounds as good as the best amps I have listened to from any manufacturer.
In the end, sound is very much like art. It is highly subjective. What is beauty to one, might be ugly to another. Please yourself. Everything else just makes for good conversation.