I don't design around a set sensitivity level per say because that doesn't take into account the power output capability of the design. Let's face it, all else being equal, an 80 watt amplifier is going to send twice the quiescent noise to the speakers than a 20 watt amplifier is, but for all practical purposes, in my listening room with Cornwall speakers, 20 watts per channel is more than enough. As a result, I take into account the total gain of the amplifier, and more typically strive for a sensitivity based on a gain of about 11 in all of my own units. That way, the 20 watt amplifier will be driven to full power with an input signal of about 1.15 vac rms, while the 80 watt amplifier will require about 2.3 vac. Both of these input level requirements are well within the capability of any good preamp, but by adjusting the sensitivity level to the power output capability, it makes for a much more practical installation in the listening room. An 80 watt amplifier with a 1.15 vac input sensitivity connected to a PAS amplifier and Cornwalls is going to be pretty noisy in my listening room, while a 20 watt amplifier with that sensitivity rating will not be -- but both can still be easily driven to full power so that the capability of both can be realized, while importantly, the volume control when using the 80 watt beast won't be operating in the weeds.
Dave