Well, from my own observation I noticed that the degree of sensitivity to temperature variation is much higher than I would have imagined.
I had my voltmeters clipped on to the test points, with the amp cover loosely in place..... simply removing the cover and allowing cool air in caused an almost immediate change in the idle current voltage. Similarly, allowing the amp to stabilize with the cover completely removed, and them putting the cover back on caused an opposite fluctuation to occur.
On my Kenwood KA-7100 I was able to get down to deviations of only a few mV from the factory spec of 20mV, so it it not tremendously significant, but still present. I finally settled for a value that hovered mostly between 20 and 22mV.... but occasionally it would move outside that range, even at idle. This was a somewhat frustrating process, as sometimes it seemed like my tweaking was actually contributing to larger variances rather than dialing it in closer to the spec'd value.
Interestingly, my Pioneer SX-880 service manual specifies a value of 30mV, but indicates that a reading within the 20mV - 40mV range is acceptable. It is within that range now, and I dare not touch it without first upgrading the stock trimmer pots with Bourns multiturn pots.
I'm sure line voltage can be a factor as well, but at least in my case, thermal sensitivity seems to be a more significant factor.