The grid resistor should not be connected in such a way that it determines negative grid voltage. And the 100K maximum recommended by tube manufacturers for the 6L6 should not be exceeded. The maximum value is based on being able to securely hold the grid at the intended DC voltage. Here's an explanation that discusses things such as positive ion current within the tube:... in order to get the bias correct I would have to use a 250k ohm resistor on a 6l6 that calls for 100k for fixed bias
Grid Resistor Value (from Morgan Jones Valve Amplifiers 4th Ed)
Jack