This topic has come up multiple times. There are basically two camps, either they are imperfect wastes of time or they are a fun way to change the sound of your system. I am firmly in the latter camp.
I have two amps made specifically for rolling different kinds of tubes. Both allow manipulation of b+ to account for tubes as different as 6f6 to kt88. The first amp I got was a Dennis Had Inspire KT88 Firebottle. It is a single ended pentode amp with a regulated screen supply as well as a regulated b+ for the dual triode driver. You can adjust the b+ for the output tubes by using different rectifiers. Use a 5y3 for something like a 6v6 and a 5ar4 or solid state diode for the bigger output tubes. I usually have some sort of 6l6-oid in there (currently a pair of 6ar6) and I use a 5u4gt. I think the maximum b+ you can get with this sort of setup is shy of 350v so you’ll never get the power out of the likes of el34 or kt88 that you could otherwise. Single ended amps aren’t really good for high power in any case IMO.
My other amp is a custom differential push pull that was built for me. No sane person would ever sell an amp like this to the general public but I’m very happy that this madman met a crazy Amp Designer/builder. It uses solid state rectification via a Maidia 21st century regulator. There is a pot allowing me to adjust the b+ between 250v-400v. It is manual bias with individual adjustments for each output tube. In addition I have banana jacks on the back that allow me to use external supplies for the heaters so I can take advantage of all of the cheaper, odd voltage tubes especially for the driver tubes. It uses Monolithic Magnetics 8k output transformers which allow both triode and ultra linear operation.
I am not privy to the feedback mechanisms used in each amp. I’m pretty sure Dennis Had is just a wizard. Single ended pentode operation is tricky in any case but he has made an amazing machine. I am seriously considering getting his parallel SEP version that uses oa3 and the like for regulation duties.
I have never understood why people are hung up on “optimizing” tube amps. Optimizing for what? Max power, lowest distortion, perfect square waves, lowest output impedance? Why are you messing with tube amps at all if those are the kinds of things you’re looking for? The only reason to use tube amps at all is because you like how they sound despite not being optimal amplifiers.
And this is where amps made specifically for rolling tubes shine. What happens when you buy an ST-70 or a Mac and your system sounds worse than before? You’d have to change an entire component of the system to rectify it. Worse still, what if you wanted your system to sound different for different kinds of music? Commence pearl clutching and mumbling that there is only one true way for a stereo system to be enjoyed… Never mind that there are loads of “optimized” amps that sound very different driving different speakers. Which optimized sound do you prefer? Conrad Johnson, Audio Research, Quad, McIntosh? It is so much easier to have one amp you can get different sounds out of.
Most importantly it is just fun to play with different tubes. It is a different way of enjoying the equipment. It is akin to cooking really. It is all done to taste. Tune rolling is an active way to interact with your system. If you like the idea of that then amps made for rolling will give you a lot of enjoyment.