Acoustic Scale
You can use the midhorns for other applications besides a constant directivity cornerhorn, yes. Some have done that, putting a midhorn on top of four π's, for example. It's a good midhorn, and could be used in a variety of applications.
But I always try to remind people that the horn was really designed for use in a constant directivity cornerhorn. That's where the magic is. While it can be placed on top of a direct radiating midwoofer, crossed-over to a waveguide/horn tweeter, I probably wouldn't do that, myself. If I don't have the right corners, I'll stick with a DI-matched two-way. Here's why:
It's all a matter of acoustic scale.
At low frequencies, the woofer is within 1/4λ of the walls and there is no self-interference from reflections. There are room modes, standing waves between opposite walls, but that's below the Schroeder frequency, under 150Hz or so. From this point up to where the woofer is 1/4λ away from the walls, the corner forms a giant waveguide. That's also why you turn the woofer around, snug it back into the corner. It needs to be close enough to the walls to be within 1/4λ through its range.
At high frequencies, the horn/waveguide sets the pattern. If you use a horn with constant 90˚ horizontal beamwidth, then the high frequency pattern matches the low frequency pattern. You can obtain directivity that is truly constant through the whole audio band, from the Schroeder frequency up. With multisubs smoothing the modal range, you can actually achieve uniformity throuout the room through the entire audio band. It's really awesome.
Think of the midhorn as an interface, between the low frequencies where the woofer is closer than 1/4λ and the high frequencies where the tweeter takes over. The midhorn is designed to be used in the 200Hz and 2kHz decade but its real strength is that it prevents self-interference from occuring. It's just large enough to set the pattern from about 500Hz up if it were used in freespace, but tucked back into the corner, it keeps control all the way down. The mouth is closer than 1/4λ at the low end, and so there is no self-interference. And above that, the midhorn profile sets the pattern, providing a constant 90˚ beamwidth to match that of the tweeter.