Bias, you say? This is the most interesting part. The 400 uses fixed bias (as do its close relatives). Since you can't do much of anything to measure, or adjust, the bias in the stock machine, you'd better use a matched quad of output tubes. Their long-term health will depend in large part upon their biasing. Prevailing wisdom suggests something on the order of 0.30 mA current, or a bias voltage of ca. -20V (or so... this is off the top of my head).
In the stock 400, the four cathodes (pin 3) of the four output tubes are all grounded. If we replace the grounds with low-value resistors, we can now actually measure the bias current by measuring the voltage drop across the (known) resistance we've added. Adding cathode resistors, although controversial, might also add a "fuse" of sorts to protect the output transformers from a tube's shorting.