Your board looks to be an early revision, the gain of Q501/502 is critical for determining DC offset and then due to a design quirk, the bias. If the gain is too low you'll get no bias, I had to go with extremely high gain parts in my unit to get it working.
Modern MPSA20s work fine to replace the original one.
It is highly recommend (honestly required if you plan to use the 250) that you pull the driver, predriver and output Transistors and test each for gain, if they are not within the proper gain range as defined by the Marantz service bulliten both the bad Transistor and it's complement needs to be swapped and matched. I have seen units where they "worked" but several of those higher power Transistors were nowhere near spec and it was only a matter of time until the 250 nuked itself.