I'm certain that they will make a positive difference for most, if not all CDPs.
I Isolated a CDP using super balls, the small ones you get for a quarter at pizza parlors and the like, and it did make a difference for the better. I reported it here, and many others have tried it, and reported the same results.
For me it was just an odd experiment, and I was surprised at the results. My son was also involved and he also was hearing the difference.
Others have used Blue tack to deaden the interior of the mostly crappy plastic cases of CP and DVD players with similar results.
I don't for a minute believe it is improving the 0's and 1's, or how the laser reads them, but the circuitry after the D to A converter can be affected. Black magic for sure, until some smart boy gets to reading the output circuitry and discovers what the heck is harmonic enough to be affected.
I suspect a CDP on an already acoustically "Dead" surface would see minimal difference. But that is just a guess. My project for a well padded and dead surface for my sources to sit on s on hold indefinitely, so I won't be able to do much about further testing in the foreseeable future. My current CDPs are not using isolation only as they lack the headroom required for the balls.