The 12AX7A has controlled hum and noise characteristics, so it would be the choice of tube for high-fidelity applications like a preamp line-stage over the non-A. These tubes can be used for many other types of application where the hum and noise would not matter, for example, my Seeburg jukeboxes use one for a pulse amplifier when reading out the selections from the core-memory. My Concertone reel-to-reel tape recorder uses one for the bias oscillator. In these applications, a plain 12AX7 would be just fine.
--Bob