Other than the actual input signal, and speakers--let's assume a clean and accurate source signal, and leave speakers out of this (due to all of the compounding issues of room/gear compatibility, design/placement and personal preferences)--the preamp stage has the greatest impact on the "sonic signature" of a system. Different circuit topology and component selection certainly does impact the "sound" of a preamp. Certain designers/manufacturers even "voice" their gear to a "house" or "signature" sound that they are known for. Some are known to be "warm", "smooth" or "laid back", while others are known to be "dark", "clinical" or "sterile", and all sorts of descriptions in-between. There are also the "compatibility" factors (like input/output voltages and impedance matching), but those are less common when pairing up gear of a given vintage/era, and should be non-existent in a receiver or integrated amp where the preamp stage was specifically designed to operate with the internal amp.
In theory, a quality amplifier should only do one thing--take the small signal from the preamplifier stage and "amplify" it to a useable output level for the speakers; however, we all know that is not 100% true (even under the best of circumstances). All amplifiers have a "pre-driver stage", and there can be "sonic artifacts" introduced at that point, as well as other limiting factors in the amplifier circuit.