No, cables make almost no difference, provided they are of low resistance. 12ga makes excellent speaker wire.
-k
Though I know your background and expertise, I have to agree and disagree. In my case, your statement is true to my Marantz SR-5001 HT Receiver and my Dayton DTA-1 amp. But, in my tube system (CJ MV-75 amp) it is a different story. I used solid silver wire 20 AWG with three strands twisted for each +/- terminal (6 strands total). Compared them to my DIY twisted 12 AWG cables. Sound from the DIY silver cables was somewhat brighter than the DIY 12 AWG, which was an improvement for my tube system, which has a lot of bass and is very warm; I use KT90 tubes. When doing the same thing with my other receivers/amps, the difference was hardly noticeable, if any.
If someone wants a good pair of DIY cables that are easy to make and look good, you can make the DIY Canare's that are a few posts back, or take 12 AWG cable (I used Vampire Wire), cut to your desired length, then twist the cables and use hot glue or other glue every 6 inches or so to hold the twist, cut 4" of heat shrink of the appropriate size to cover the ends of each cable "leg"; I used red for + and white for -, apply heat to shrink the tube, if you want you can put cable pants at this time, then cover the complete cable with heat shrink tube and cut about 1/2" after the "legs" start or the pants begin, apply heat to shrink, for banana terminals I didn't want to solder (it is up to you), so I used
Monster QuickLock Banana Plugs on one end, the other end I used
spades for vintage binding posts.
In the DIY forum here you can find a sticky thread of people showing their DIY cables and you will find many ideas there, mine are somewhere there.
I'm a believer of system synergy of all it's components, including speaker cables and interconnects. Having said that, I will not get into a debate regarding the subject. This is highly subjective, and your point of view and findings might not only be determined by measurements or how sensitive to sound you are, but there might also be a psychological factor. The probability is that 99.9% of the people weighing in on the subject are not Psychiatrists, and regarding experimentation and measurements only a few have done it. Personally, I have done listening comparisons with my equipment, but not taken measurements.