Current favorite-
Lio- reminds me of the vintage & macabre Addams Family comics I'd read as a wee lad out of the New Yorker. "Lio" is done by Philidelphian Mark Tatulli, age 43, a very busy fella. He also writes and draws another strip called "Heart of the City" and is a post-producer for cable tv's "Trading Spaces" and "A Wedding Story" programs.
Howver, my favorites (besides Lio) are only online. I prefer Red Meat written and drawn by Max Cannon, followed by The Angriest Dog in the World, a strip by David Lynch of Twin Peaks/Mullholland Drive/Eraserhead film fame. And Maakies, by tony Millionaire, is another favorite. Love Uncle Gabby and Drinky Crow! Tony Millionair also wrote Sock Monkey.
But be forewarned- Maakies sometimes delves into pretty adult themes. Same for Red Meat. The jokes are not always tasteful, and sometimes I don't laugh. But when they get 'em right, they're good. As for Angriest Dog, well, it's certainly an aquired taste.
Mutts is a guilty pleasure. Simple and innocent, I can't quite figure why I'm endeared to it. Yesh indeedy....
Non Sequitur was a favorite- though recently it's taken a strange bent to it. Absolutely love the gothic flavor and illustration, just not jiving with the new serious tone. No sweat, good luck to the artist and his new direction.
Pearls Before Swine has been getting better and better. Especially love the Louisiana/cajun accented alligators, and the naughty pot-shots at Bill Keane and Family Circus. Naughty, but makes me laugh.
Bizarro strikes a funny bone once and a while.
Same for Dilbert, which I used to enjoy. But the office jokes are starting to age on me.
Both Far Side and Calvin and Hobbes are legendary, and sorely missed.
I've been told I'd have loved Krazy Kat. Sadly, never seen it.
To this day, I'm still not hip or esoteric enough to figure out Zippy Th' Pinhead.