The best bias level, in milliamps, depends on the tubes in the outputs.
I've used original Fisher branded Sylvania 7868s (clear glass with yellow lettering and top getter) at 18 ma and I've been happy. Then again, they weren't the strongest. They were well ripened.
Typically I head for high 20s to low 30s with tubes of this vintage though, with both 7868 and 7591 output tube types.
With EHs and lowered grid bias resistors with .1uf caps upstream in a 500-C, 25ma will do it, mid 30s really makes it rock and brings it to life.
With Westinghouse 7591s, even low 20s is fine, but again, more life at a higher dissipation.
So the answer is . . . it depends.