I'm gonna' have to think about this one... I'm more of an album person myself. And there are lots of big ones for me.
"461 Ocean Blvd" instantly comes to mind because it was one of my mother's favorites when I was a kid, and I remember hearing it on Saturday mornings while she was cleaning around the house. Those were good times (She was a working mom, and this was about 5 years after my dad's accident, so the weekends meant a lot because she was home... So all the music she played on an old tube console setup she had, that stuff really brings me back to those days when I was 5, 6, and 7 years old. Carole King, Joni Mitchell, CSN&Y, Dylan, Arlo Guthrie, Peter, Paul, & Mary, Jefferson Airplaneship, etc. That was her s**t.
The best-of set that's playing right now. The Spinners. "Definitive Soul Collection" 2 discs. LOVED the Spinners when I was a kid. Most people forget how many hits they had. I grew up on those guys. They had a LONG string of hits.
Also, oddly-enough, KISS's "Double Platinum". Got it on 8-track when it first came out and played the bejesus out of it (Them... It was a double-album). The music really got overshadowed by the hype, which is a shame because there's some great stuff there, especially the Gene Simmons tracks. And that stuff sounds awesome through the W90's (They can do some amazing things with multi-tracked recordings).
And one of my all-time favorites, "The Best Of Sam & Dave". Nuff said.