It is an interesting question which deserves serious discussion. One which goes beyond "I think there is a difference so there is!"
I have given this question much thought and the fair amount of study. I think there is a discernible difference and the difference is the result of the designer's chosen topology. There seems to be broad agreement, for example, that there is a distinctive Marantz sound and a distinctive Sansui sound – and Nelson Pass's minimalistic class A designs also have a distinctive sound of their own, which many people love! Rod Elliott has a variety of superbly designed amplifiers and preamps, at least one of which has an amazingly devoted following… The P3A? Can't remember

. People with much better ears than I say it has a remarkable sound.
And I believe that the topology extends down to the particular amplifying devices – tubes have a sound of their own, as do mosfets and jfets and the various "chipamps". I have a few chip amps and think they're great – but I find the sound too bright and harsh; and I wonder if that is because they are much more accurate than the old stuff I'm used to listening to? Is that wonderful "brown sound" the result of hundreds of components gracefully gliding out of spec over so many years?

. Are some things better when they are not new, precisely because they are not new?
And I have always found it interesting that Douglas Self's probably brilliantly designed (I'm not well-schooled enough to know just how "brilliant" it is…) "Blameless amplifier" never found a place in the list of classic amplifier designs. Was it so close to being a straight wire with gain that it had little sonic interest?
I would love to hear comments on these questions from those of you – and there are many! – With better minds than mine.