On a bass amp I have made to run 6L6GCs in a PP AB config with a 450VDC B+, the OPT with its 5500 ohm primary is a perfect match for the 5600 ohm plate resistance of the tubes. The 4, 8 and 16 ohm secondary taps, are 4, 8 and 16 ohms. I am using an 8 ohm speaker on the 8 ohm tap. Easy.
If using alternate tubes with a different plate resistance presented to the primary, you effect the secondary impendence. You can find the new secondary impedance with some simple math by using the plate resistance of the tubes in use and knowing the turns ratio of your transformers you can find the impendence ratio. I decided to use 6550s in that amp (a popular option for this amp) with 3500 ohm plate resistance. The ZR of secondary taps with the lower primary presented came out to 2.5 ohm, 5.2 ohm and 10 ohm down from 4, 8 and 16 ohm. I tried both the now 5.2 and 10 ohm taps with my 8 ohm speaker. The 10 ohm tap was by far the better choice. The amp was louder and really opened up.
All this to say, yeah which ever one sounds better...