not being a musician I am in no way qualified to say who is best, but I heard Eric Clapton say Buddy Guy was the best guitarist alive. He may of just been showing respect to the old master, but Buddy was amazing in his prime. Played with as much soul and feeling as anybody. My money is on Danny Gatton (RIP) because it was natural. He could play any genre, was nicknamed "The Humbler" because any guitarist who heard him play walked away knowing Danny was better. Judging guitarists is fun, we all like different things, but kinda like saying who is the best looking women. (or man for the ladies reading) I am lucky to have grown up near DC, we had Gatton, Buchanan, Link Wray, Tom Principato, as well as Stuart Smith (Eagles studio and touring guitarist), Danny Morris (very good surf influenced), Bill Kirchen, (Grammy nominated) Eddie Angel (Los StraightJackets, Switchbade) Nils Lofgren (solo and Springsteen) and am sure I forgot some- like Bo Doddley.