I have had the C220 and the C46, I think they both have their strengths, I personally preferred the C46, it's a smooth and transparent pre, I found the C220 not enough for what I liked in a sound (lacked transient detail). What I did find is that if you have a bright CD etc I would use C220 to counter otherwise I would go for C46. I also found if you have very efficient speakers the C220 seemed to do better. I myself use inefficient speakers so liked the C46, in fact I would say its most probably one of my all time favourite pre’s.