ETA: in my experience, they need to go into a preamp that can really crank up the line voltage to something that makes the main amp sing. I use a "stage" preamp that can put out 11 volts. I never crank it up past about 1/2 way - but knowing it can "go to 11" (LOL) means I have some headroom on the signal going into the amp.
I am also running a stage EQ that I run at line level - so I can see both whether I am clipping "going in," or "going out" (it's selectable) on the EQ. I think with that preamp, I could probably way overdrive the final amp - so having those VU meters helps me sleep at night.