It is possible and has been done. When the results come back from this type of test, it shows that the differences are much smaller than people expect, so some immediately fault the test rather than accept what the data is reporting.
I'm one of those people and its not because I don't expect the results of the test. I fully expect that given unfamiliar music, a different listening environment, unfamiliar speakers, the routing of the signal through some switching apparatus, the change in listening mentality because you're now in a 'test', the short time of listening instead of the hours or days often needed to tell if something is really more enjoyable to listen to, the mental bias that happens when you're removed from your own comfortable environment, the onset of group think, the fact that even MP3s passed a number of blind tests, that there was one test where people said a clock radio sounded like a real instrument (wish I could find the link to that one) and of course not to mention that often some extreme percentage of choices must often be right in these tests for there to be an admitted difference..say, if 75% of somebody's answers indicate a difference and a better than 90% correct score is needed, then the 75% is not payed any attention to and written off as chance because somebody else who may not have as trained of an ear or who's mentality was more affected by the foreign aspect of the test environment got 25%...and...and...that all amps will sound the same to a group of random people. Add to that the fact that I don't believe there are huge glaring differences to begin with that stand out in short listening sessions...at least not ones that are important to most people..then yeah, it doesn't surprise me one bit.
Oh, yeah, I forgot. I really don't care about science applied to my leisure activities. Cheers!
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Then there's the fact that just about every leisure activity you enjoy, such as posting to AK on a PC over the internet to a central server and database, involved a huge amount of technology based on scientific research. Vinyl? Science. Tubes? Science. Transistors? Science. Jogging shoes? Science. Golf clubs? Science. ad infinitum...