^^^
You can, but it's inconvenient at best because the signal to the sub would not change with the volume control. At worst, may not have enough signal to drive the sub to max output (depending, of course if, one actually needs to, gain of sub amp, sensitivities, etc., etc., etc.)
In this case, if the OP went with a powered sub, putting the Bose EQ in pre out/main in probably is the only real choice. The input to sub and Bose EQ could be split off the pre out with Y cables, then the Bose EQ output would be looped back to the main in. Any other way can think of puts a Bose EQ curve to the sub too and that's not desirable at all.
OTOH, if the OP actually puts the Bose EQ into the system, there may not be a strong desire for more bass.