Some preamps are meant to stay on 24/7, and I think it's safe to do so as long as you replace capacitors in the power supply and whatnot if it's an older unit. If you go away for long periods of time, it's a good idea to unplug it, but otherwise, it's probably OK to just let it be. My Superphon Revelation preamp had no power switch (just one marked MUTE/PLAY), and it had no problem being left plugged in all the time, and while the filter capacitors did eventually fail, nothing ever actually blew up inside it or anything like that.
-Adam