Be careful if your amp is DC coupled, the folks from Little Dot have said that when used as a preamp it can pass dc to a DC coupled amp and damage your speakers. I was going to buy one but that changed my mind.I'm pretty sure you really will like the D10, but if not you should be able to get most of what you spend back out of it... interesting you mention the Little Dot MKII, I just got one a couple days ago via Massdrop. Also ordered the Soviet made Voshkod driver tubes and the power tubes from Russia and they arrived in time as well.
It's my first tube powered headphone amp and so far I really like it. I've been using a Chinese tube buffer/preamp between my DAC and the Objective 02 headphone amp that I've been running up until now.
The D10 seems to be a good match with the Little Dot. I'm also running the preamp out of the Little Dot to my desktop near field setup, sounds great!
Thanks, I read about that... I have it hooked up to a TPA3250 based chip amp (FX502S PRO) in my desktop computer near field system; it has coupling capacitors (not direct coupled) so I think I'm good to go. Sounds fine so far, no problems.Be careful if your amp is DC coupled, the folks from Little Dot have said that when used as a preamp it can pass dc to a DC coupled amp and damage your speakers. I was going to buy one but that changed my mind.
Interesting, mine definitely has them... maybe an earlier version didn't?The Little Dot MKII that I mentioned isn't designed to be used as a preamp as it has no outputs other than a single 1/4" headphone jack.

Question! Since the D-50 has a volume control, can I hook it up to an amp directly and kinda using it as a pre?
That is really an amazing deal... tempting!The D-50 is available again on massdrop for $199 and worth every penny. These drops don't last long.
https://www.massdrop.com/buy/topping-d50-dac?mode=guest_open&utm_campaign=Drop: Request Launched&utm_source=SparkPost&utm_medium=email&utm_term=Drop: Request Launched&utm_content=1526303142761.413878805573886708404777&referer=ZU39SC&utm_content=1526303142761.413878805573886708404777

Hate to play contrarian - and I generally agree with you - but I think that only applies to the internal soundcards. You might be on to something though.
I'm having a hard time deciding whether this would be an audible upgrade in my modest vintage system from my Creative USB external "audio interface" (EMU 0202 USB; has inputs for mics and instruments) which I bought years ago for $50 and use as a soundcard. I tend to think that most improvements in soundcards/DACs come from moving it out of the motherboard area. It already sounds as good as my CD player so not seeing much room for improvement.
Looking at your equipment list in your signature, I think you would probably see some improvement going with any decent stand-alone DAC. The D50 would be a good fit. What's your music source?
The Little Dot MKII that I mentioned isn't designed to be used as a preamp as it has no outputs other than a single 1/4" headphone jack.