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Coronavirus Is Evolving

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The news out of Pfizer and Moderna is very good, and the BETTER news is that their new vaccines (they're very close in design) can be quickly taylored to mutations.

They are already in production. There's more vaccines following them.

It's possible that we might see a historic event - an amazingly fast response to a global pandemic, with a positive outcome.

The real heroes here? The scientists who were working hard, and their friend, the supercomputer..
 
How are you doing and how's the situation in your area?

The project I am working on is down to about 60 people as of today from 132, this has been over the last week. Only a couple of positives, the contact tracing is what is making them drop like flies. Just about zero opportunity for social distancing. One silver lining is the airport and plane should be about empty when I fly home.
 
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The county here in good ol' Idaho that is now in trouble with a shortage of hospital beds, actually held a series of anti-mask rallies a few months ago.
I know ID well. Father in law lived there. Bonner General is struggling with resources. Folks there were very laissez faire while this was brewing elsewhere.
 
Guess were lucky up here.Not one person has been hospitalized period.We were late to the mask thing also.Population is approx. 78000 or so.Bordertown with Soo Michigan.
 
As mentioned earlier, a virus tends to adapt to changing environments and can develop end runs around currently effective treatments. Not seeing a lot of info or speculation as to how the new rDNA vaccines will respond to any changes in the virus, but there's high hopes that they can either handle such changes as is, or be fairly easily modified as needed. We already do that with other vaccines - think flu. What's scary is, we've already seen instances of inter-species transmission and mutation, and that's got some experts running scared.

Still, the biggest hurdle will be getting folk who can't be bothered with basic proven hygiene practices to "submit" to getting vaccinated. I'm talking those who's personal "rights" far outweigh those of the rest of us - at least in their own heads.

Oh. This rDNA thing is showing positively outstanding results, so yet another example of real science saving the day. There's also talk of application in other serious health threats, including AIDS and even cancer treatment. Mayhaps a positive result of a crisis which to this point hasn't had much in the way of a bright spot. Also worth mentioning is ebola research - that vaccine also requires super cold storage (super thermos), and a lot of work went into developing self powered mini-freezers to make distribution in remote areas possible. I for one would like to see resources available to start producing those in the quantities necessary. We did that with ventilators - we can do that with any other tools needed to get us over the hump.

Another pleasant surprise might be having this officially declared a national emergency, which would make it a lot easier to mobilize the National Guard, Corp of Engineers, and other pertinent federal agencies, expediting access in remote areas to the resources they need to combat the pandemic. FEMA can also work wonders when given the opportunity.

That said, my soapbox is currently feeling a bit rickety, so I now return control of your television set ... ;-}
 
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The vaccines use messenger RNA not recombinant DNA. The former is much, much (much) safer as a strategy -- they can neither integrate into the host genome nor mutate. Also, because the nucleotides are built around ribose rather than 2-deoxyribose (the "R" vs. the "D", respectively), they're much less stable -- which is good. You want 'em to do their job (i.e., get translated into immunogenic viral protein in situ in the immunized "patient") and go away.

EDIT: It might be worth mentioning that the coronavirus responsible for COVID-19 is a (single-strand) RNA virus -- but then again it might not. The viral RNA has nothing to do with messenger RNA (the template that actually encodes ribosomal biosynthesis of proteins, known as translation) -- well -- other than encoding the complementary sequence of ribonucleotides that will make up the mRNA and being made of the same kind of ribonucleotide building blocks.
 
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